This property of the packaging helps to measure the strength and quality of the materials and helps to determine the suitability of the material for different applications. Our materials testing machines and force measurement instruments are used worldwide to verify package integrity and suitability for transportation, storage and for safety and consumer protection. If your packaging requires special testing, the same machine can be set to perform customised tests. The MultiTest-xt is a versatile tensile & compression tester controlled by a touchscreen console. The twin-column range can be mounted neatly on your bench-top and is ideal for product testing applications according to your own test methods. The MultiTest-i is a versatile tensile & compression tester controlled by software running on a PC. Mecmesin supplied a Coefficient of Friction test system, capable of measuring both the static and kinetic coefficient of friction values.
This test is designed to evaluate responses to the instillation of extracts of material under examination in the eye of a rabbit. 2 Systemic injection test; Intracutaneous test Comply with the tests described under Plastic containers for Parenteral Preparations. Comply with the tests described under Plastic containers for Non-parenteral Preparations. The principle involved in the powdered glass test in estimate the amount of alkali leached form the glass powder. The amount of acid that is necessary to neutralize the released alkali is specified in the pharmacopoeia. In this test, surface area does not increase as much as volume with the increase in container size, consequently, the small sized containers are more attacked by the leaching of the alkali from the surface. Glass is a common material to be used in either no sterile or sterile liquid dosage forms. Hence, a limit test for alkalinity is to be performed before using it for a particular product. Soda-lime-silica glass is a silica glass containing alkali metal oxides, mainly sodium oxide and alkaline earth oxides, mainly calcium oxide.
Plastics are synthetic or semi synthetic viscoelastic materials composed of organic polymers and organic or synthetic additives. The behavior of plastics under stress depends on the length of time they are exposed to the stress and the temperature the exposure occurs. The applications for plastic materials are broad because the mechanical properties of plastics are defined by their molecular makeup which may be customized to meet the requirements of the desired application. The more common forms of plastics and their applications are styrene foam or Styrofoam which is used as insulation and packaging, PVC which is used in plumbing and nylon which is a flexible yet strong material used in the clothing industry. Thickness is an important property of a packaging material and critical for other mechanical properties, such as permeability, tensile strength, impact resistance, etc. Besides, it is an efficient way to reduce production cost by controlling material thickness within reasonable range. Hexa plast is a world class manufacturer and exporter of various type of plastic process laboratories testing machineries.
We are now partnering with that facility to get their equipment up to optimal performance and to provide our technical services. Our test box has an electrically driven ram that will push that disc out the same distance each time, at the same speed, with the same force each time, so there’s no bias. Our test environment removes inconsistencies so we’re able to capture an accurate measurement for comparing films. Load containment is the ability of the film to prevent palletized loads from shifting by offering enhanced resistance to being further stretched. It’s measured by a load cell attached to a ram/plate combination which is extended into the film a specified distance. At a given turntable speed, we will determine what prestretch level and F2 setting will provide the best balance of puncture propagated tear resistance and load containment for a particular film. Typically, we can present a customer with a proposal for a new film, upgraded or serviced equipment, and new application settings that can save significant amounts of money and put out a better performing wrapped pallet that avoids load failure . John Cook is a polymer chemist who has been innovating polyethylene resins and films since 1973. John’s work at Atlantic brings material knowledge and insight that benefits our customers. High quality, dependable, and optimized packaging equipment is the cornerstone of what we can offer our customers.
In this case, it is fundamental to ensure that the samples undergo the same processes. There is also, however, the option of including different sample preparation methods as part of the comparison test method. Moreover, parenteral formulations are chemically complex and diverse, thereby having variable and potentially aggressive “leaching powers” and presenting potentially great challenges with respect to their analytical characterization. Furthermore, the conditions of contact between a parenteral and its packaging can be relatively harsh, increasing the likelihood of leaching. For example, packaged parenterals may be subjected to high energy sterilization or may have relatively long shelf lives. In addition to the high risk associated with a parenteral and its packaging, parenterals and their packaging have certain unique features which complicate the chemical and biological safety assessment. First, parenteral packaging is compositionally diverse, consisting of a multitude of materials of construction including elastomers, glass, stainless steel, LDPE, HDPE, PP, PETG, COC, COP, PVC, multilayer films, etc. As such materials will have varied and potentially complex compositions, the universe of potential foreign drug product impurities is large and chemically diverse. Polymers and polymer-based composites represent the largest and fastest-growing area of materials for engineering and other structurally-demanding applications.
Often the package is conditioned to the specified environment and tested under those conditions. With some testing, the package is conditioned to a specified environment, then is removed to ambient conditions and quickly tested. With some types of packaging such as food and pharmaceuticals, chemical tests are conducted to determine suitability of food contact materials. Testing programs range from simple tests with little replication to more thorough experimental designs. PET containers have numerous points of interest over different structures, similar to, glass. These are a portion of the regular advantages of utilizing a PET, yet the greatest preferred standpoint is that it is anything but difficult to re-evaluate the plan of plastic pressing in the event that it is bombing over and again. The revaluation procedure does not cost the fortune to the organization but rather unquestionably requires a correct testing process.
For an SVP with a daily dose volume of 10 mL, the resulting AET of 0.15 µg/mL can be challenging to achieve in chemically complicated parenterals. For an LVP with a daily dose volume of 1 liter, the AET of 1.5 ppb can be challenging in even the simplest parenteral drug product. Such an “AET challenge” makes extractables and leachables profiling even more difficult. Simply stated, the health of patients using drug products is adversely affected in direct proportion to the dose of leachables to which they are exposed, with the greatest adverse effect occurring at the highest dose of the most toxic substances. Parenterals are classified by volume; a small volume parenteral has a solution volume per unit package of 100 mL or less and is intended for intermittent intravenous administration (usually defined as an infusion time not lasting longer than 6-8 hours). SVPs can be packaged in ampules, vials, prefilled syringes, bottles, and plastic bags. If the friction of a material is too high then the film may too ‘tacky’ for the process, too low and the film may be too ‘slippy’ for the process. Optimising friction parameters can help understand how the finish of a blown film can influence the feeding and running speed. Surface slip is a key factor when printing or filling packaging materials on an automated line.
Our experts can provide consultative support at every stage of the extractables and leachables process, from understanding extractables and leachables regulatory requirements to deciding on a suitable test strategy to decoding the results. We will work with you to understand you requirements, address your needs and deliver the required results to support your regulatory submission and protect patients. We proudly hold certifications that show our dedication to supplying packaging that meets the most demanding industry standards. We offer innovative packaging solutions with abundant material and feature options to a diverse base of markets. We saw that they were applying film to every single load as if it weighed 2500 lbs. So the loads that weighed a lot less were being wrapped as if they weighed the maximum. Throughout the 1990’s and 2000’s, John helped develop industry leading stretch films for Linear Films and Pliant Corporation, later acquired by Berry Plastics. A number of leading stretch films were developed under his direction, including ADW and ADU at Linear and R122, R410, folded edge Stratos cast handwrap, and Stratos machine films at Pliant.
Since our inception, we have been focused on delivering the optimum value to our customers, in turn, achieving maximum possible customer satisfaction. We make sincere efforts towards the same by indulging in research and development activities, so as to create innovative offerings for our customers. We ensure that our offerings are in compliance with the highest industry standards. Packaging for medical materials, medical devices, health care supplies, etc., have special user requirements and is highly regulated. Barrier properties, durability, visibility, sterility and strength need to be controlled; usually with documented test results for initial designs and for production. Dynamic compression is sometimes tested by shock or impact testing with an additional load to crush the test package. Packages are usually tested when there is a new packaging design, a revision to a current design, a change in packaging material, and various other reasons. Testing a new packaging design before full scale manufacturing can save time and money. With distribution packaging, one vital packaging development consideration is to determine if a packaged-product is likely to be damaged in the process of getting to the final customer.
The machines last long and you seldom have to look for any kind of major repair work. These relatively simple test methods typically evaluate a narrow aspect of an innovation or a package component on recycling. For example, a screening test might evaluate how well a closure or label floats in water, or measure discoloration in PET flake from an extrusion or injection molding heat history. Many of these tests use commonly available equipment and can be employed in a variety of laboratories. Before the test, preset the heat seal temperature, pressure and dwell time value, place the specimen in between the upper and lower jaws, and then press start button. Packages can degrade with exposure to temperature, humidity, time, sterilization (steam, radiation, gas, etc.), sunlight, and other environmental factors. For some types of packaging, it is common to test for possible corrosion of metals, polymer degradation, and weather testing of polymers.
It is equipped with three individual test dishes and the testing process is completely automatic and conforms to international standards. For example, FSSAI have standards such as IS for checking contact of Polyethylene with foodstuffs, IS for checking Styrene Polymers contact with foodstuffs, and others. These standards are verified using packaging testing equipment by testing plastics which is in contact with food items. The tear-away seal on a single-use container was delaminating instead of cleanly separating from the lip of the container. A customized grip method was created for the Mechanical Test System and containers which had been sealed by different methods were opened by the instrument. The bad seals failed under a lower tensile force than that required to open the good seals. Inconsistent extrusion conditions had caused poor adhesion in regions of the sheets of material used to make the seals. Depending upon the expected stresses and loads of the application any number of tests will be performed upon a plastic material to predict its behavior under those forces.
This is because plastic components contain other substances, such as plasticizers, stabilizers, antioxidants, pigments, lubricants and possibly residues from polymerization. Therefore, for components that are in direct with the product, this testing is required to ensure that the product is not affected during its life. When the components have been identified for a particular product, the validation of packaging operation is required. This is to ensure that a consistent pack quality is obtained at the required packaging rate. USP and IP provide two tests to determine the chemical resistance of glass containers. Ensure that the highly useful testing device can measure the bursting strength of the materials such as corrugated boxes, papers, cartons, multi-layered boards, single layered – boards, etc. Packaging products play a significant role to define the quality of the products. Packaging helps to keep the domestic as well as industrial products safe and unaffected from all sorts of interference and external impacts. Moreover, the prime factor of packaging is to make the products appealing and present in front of the customers beautifully. If the product does not appear good, it can directly disturb the quality of the products and can also modify the buying decisions of the customers.